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The Alkynyl-Containing Compounds from Mushrooms and Their Biological Activities

Summary

This research provides a comprehensive review of chemical compounds called alkynyls found in mushrooms and their potential medical benefits. The study catalogs 213 different compounds that could be useful in developing new medicines. Impacts on everyday life: – Could lead to new antibiotics to fight bacterial infections – May help develop new cancer treatments from natural sources – Provides scientific support for traditional medicinal uses of mushrooms – Could result in new antifungal medications – Helps validate mushrooms as valuable functional foods

Background

Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are composed of water (85-95%), carbohydrates (35-70%), proteins (15-34.7%), fats (<10%), minerals (6-10.9%), nucleic acids (3-8%), and vitamins. They serve as a crucial natural source of bioactive secondary metabolites, with recent advancements leading to the isolation of several alkynyl-containing compounds with potential medicinal uses.

Objective

To systematically compile and review 213 alkynyl-containing bioactive compounds isolated from mushrooms since 1947 and summarize their diverse biological activities, focusing mainly on cytotoxicity and anticancer effects. The review aims to provide a detailed and comprehensive reference for the chemical structures and bioactivity of alkynyl-containing secondary metabolites from mushrooms.

Results

The review identified and characterized 213 alkynyl-containing compounds from mushrooms, categorizing them into fourteen distinct groups. These compounds demonstrated significant biological and pharmacological activities, including antitumor, antibacterial, antifungal, insecticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. The study found that antibacterial activity was the most prevalent among the identified compounds.

Conclusion

The comprehensive review provides valuable insights into the structural diversity and biological activities of alkynyl-containing compounds from mushrooms. The findings suggest strong potential for future pharmaceutical applications and drug development. The publication of multiple mushroom genomes that produce these compounds provides essential sequence information for understanding their biosynthesis pathways.
  • Published in:Natural Products and Bioprospecting,
  • Study Type:Review,
  • Source: 10.1007/s13659-023-00416-w
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