Synthesis of silver nanoparticles using Eucommia ulmoides extract and their potential biological function in cosmetics
- Author: mycolabadmin
- 7/29/2022
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Summary
Scientists created tiny silver particles using a Chinese medicinal plant extract and found they could help skin look lighter and younger. These particles work by reducing dark pigments and protecting skin from oxidative damage. The nanoparticles were safe at low doses and didn’t harm skin cells, making them promising for use in cosmetic products.
Background
Silver nanoparticles (AgNPs) synthesized from plant extracts have emerged as a rapidly growing field with applications in pharmaceutical and clinical contexts. Eucommia ulmoides is an economically important tree species used in traditional Chinese medicine with high medicinal value and contains various reductive bioactive ingredients.
Objective
The purpose of this research was to develop a novel biosynthesis method for silver nanoparticles using Eucommia ulmoides leaf extract as a reducing agent and to explore their potential biological effects including antioxidant activity and anti-tyrosinase activity.
Results
AgNPs exhibited a characteristic absorption peak at 430 nm with particle diameters ranging from 4 to 52 nm (average 17.76 nm). Zeta potential was −30.5 mV indicating good dispersion stability. AgNPs suppressed tyrosinase activity in both mushroom tyrosinase and A375 cells, and diminished ROS formation in HaCat cells without significantly affecting cell viability at concentrations below 25 μg/L.
Conclusion
AgNPs synthesized using E. ulmoides leaf extract demonstrated strong antioxidant properties and anti-tyrosinase activity under non-toxic concentrations, suggesting potential application as a whitening agent in cosmetics. The flavonoid and phenolic substances absorbed on the AgNP surface contribute to their biological efficacy and safety profile.
- Published in:Heliyon,
- Study Type:Experimental Research,
- Source: PMID: 35942280, DOI: 10.1016/j.heliyon.2022.e10021