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Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery

Summary

Scientists created a new type of yogurt that contains beneficial bacteria and special prebiotics from rice straw. The innovation uses tiny nanoparticles to protect some of the prebiotics so they reach your gut intact, while free prebiotics immediately feed the beneficial bacteria in the yogurt during storage. This dual-delivery approach keeps the yogurt fresher longer while ensuring you get maximum health benefits for your digestive system.

Background

Synbiotics combine probiotics and prebiotics to enhance gut microbiota and overall health. However, prebiotics may be consumed by probiotic bacteria during storage, diminishing their intended effects. PLGA nanoparticles offer a promising solution to protect prebiotics from premature consumption while maintaining probiotic viability.

Objective

To develop and evaluate a novel dual-delivery synbiotic yogurt incorporating rice straw hemicellulose hydrolyzate (RSHH) in both free and PLGA-encapsulated forms. The aim was to enhance probiotic viability during storage while ensuring controlled release of prebiotics in the intestine.

Results

RSHH yielded 0.5 g/g hemicellulose with 48.3% reducing sugars and 45.59 µmol Trolox/mg antioxidant activity. It reduced EAC cell viability by 61.98% and enhanced growth of beneficial bacteria better than inulin. RSHH-PLGA nanoparticles achieved 38.77% encapsulation efficiency with 204.9 nm size. Dual-delivery yogurt demonstrated optimal probiotic viability throughout storage.

Conclusion

This study presents a successful synbiotic yogurt formulation with dual-delivery of RSHH that enhances both immediate probiotic support and sustained prebiotic delivery. The approach offers a promising solution for developing functional foods with improved gut health benefits and extended shelf stability.
  • Published in:NPJ Science of Food,
  • Study Type:Experimental Research,
  • Source: PMID: 40825779, DOI: 10.1038/s41538-025-00539-z
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