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Submerged Fermentation of the Edible Mushroom Pleurotus ostreatus in a Batch Stirred Tank Bioreactor as a Promising Alternative for the Effective Production of Bioactive Metabolites

Summary

This research demonstrates a more efficient way to produce beneficial compounds from oyster mushrooms using fermentation tanks instead of traditional mushroom farming. The process can create both known health-promoting substances and new compounds with potential medical applications. Impacts on everyday life: • More affordable and sustainable production of mushroom-based health supplements • Faster development of new mushroom-derived medicines and nutraceuticals • Increased availability of natural antioxidant and cholesterol-lowering compounds • More environmentally friendly production of beneficial mushroom compounds • Potential for new treatments derived from newly discovered compounds

Background

Many mushrooms are recognized for their health-promoting benefits beyond nutritional value, particularly in Traditional Chinese Medicine. At least 270 mushroom species have therapeutic properties. Pleurotus ostreatus (oyster mushroom) has gained interest for its gastronomic value and nutraceutical properties including antioxidant, antitumor and cholesterol-lowering activities. While mushroom products typically come from field-cultivated fruiting bodies, submerged cultivation offers advantages of faster production of biomass and metabolites with reduced contamination risk.

Objective

To investigate the potential of submerged fermentation for producing bioactive metabolites from Pleurotus ostreatus in a batch stirred tank bioreactor, and to isolate and identify the compounds produced through this bioprocess.

Results

Nineteen metabolites were isolated including fatty acids, phenolic metabolites, nucleotides and alkaloids. Novel compounds isolated for the first time from Pleurotus strains included trans-3,4-dihydro-3,4,8-trihydroxynapthalen-1(2H)-one, indolo-3-carboxylic acid, 3-formylpyrrole and 4-hydroxybenzoic acid. The established bioprocess successfully produced known bioactive compounds typically found in mushroom fruiting bodies while also yielding novel compounds with pharmaceutical potential.

Conclusion

The submerged fermentation of P. ostreatus in a bioreactor proved to be a promising alternative for producing both known and novel bioactive compounds. The process offers advantages over traditional field cultivation including faster production, better control, and greater efficiency for industrial scale production of nutritionally and pharmaceutically valuable compounds.
  • Published in:Molecules,
  • Study Type:Laboratory Research,
  • Source: 10.3390/molecules17032714
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