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Structural Elucidation of Heteropolysaccharides from the Peach-Shaped Dictyophora indusiata and Its Anti-Inflammatory Activity

Summary

Researchers extracted polysaccharides from peach-shaped bamboo fungus (Dictyophora indusiata) and discovered they contain beneficial beta-glucans. When tested on human immune cells triggered to become inflamed, these polysaccharides reduced inflammatory markers and messenger proteins. The compounds were found to be chemically stable under various conditions, suggesting potential use as a natural anti-inflammatory supplement or food ingredient.

Background

Dictyophora indusiata is a valued edible mushroom with bioactive polysaccharides showing anti-inflammatory, antioxidant, and antibacterial properties. Previous research focused exclusively on mature fruiting bodies and mouse macrophage models. The peach-shaped developmental stage and its volva contain underutilized bioactive compounds.

Objective

To isolate and characterize heteropolysaccharides from the volva of peach-shaped D. indusiata (DIVP) and evaluate their anti-inflammatory activity in human macrophages. The study aimed to determine structural composition, physicochemical properties, and effects on LPS-stimulated human U937 cells.

Results

DIVP comprises glucose, glucuronic acid, galactose, and mannose (96.6 kDa) with a backbone of →3)-β-D-Glc p -(1→ units and branching patterns. DIVP is a semi-crystalline polymer with excellent thermal and physical stability. DIVP significantly downregulated pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8) and altered phosphorylation of 16 proteins in LPS-stimulated U937 cells.

Conclusion

Peach-shaped D. indusiata contains polysaccharides primarily composed of β-1,3-glucan with stable physicochemical properties and moderate anti-inflammatory activity. These findings support potential applications as anti-inflammatory agents and functional food supplements, warranting further investigation of structure-function relationships.
  • Published in:Foods,
  • Study Type:Experimental Research,
  • Source: 40361618
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