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Special Issue: Marine-Derived Compounds Applied in Cardiovascular Disease

Summary

This collection of studies explores how compounds from ocean sources like seaweed, fish, shrimp, and microalgae can help protect heart health and prevent cardiovascular diseases. Researchers examined various marine ingredients and found they can reduce inflammation, lower cholesterol, reduce blood pressure, and prevent blood clots. The findings suggest that marine-derived products could become safer, more affordable alternatives or complements to current heart disease medications while supporting sustainable ocean resource use.

Background

Cardiovascular diseases are the leading cause of death worldwide, with current preventive and therapeutic approaches often associated with high financial costs and adverse side effects. Marine sources and by-products are rich in bioactive compounds with strong cardio-protective properties that offer promising alternatives for developing natural products with health-promoting properties against these disorders.

Objective

This special issue highlights the importance of bioactive compounds derived from marine sources and their related by-products as inhibitors and modulators of cardiovascular disease mechanisms. The collection includes research on the isolation, identification, structural elucidation, and pharmacological characterization of marine-derived bioactive compounds for the prevention and therapy of atherosclerosis and cardiovascular disease.

Results

Contributions demonstrate the multifaceted therapeutic potential of marine bioactives including Fucus vesiculosus extracts regulating lipid metabolism, microalgae-derived oxylipins with anti-inflammatory properties, labdane diterpenes as vasodilators, shrimp lipid bioactives with cardioprotective properties, marine-derived peptides with antihypertensive effects, and various marine compounds effective in multiple cardiovascular conditions.

Conclusion

Marine-derived compounds demonstrate significant potential for cardioprotection and therapeutic applications across multiple cardiovascular diseases. Future research should focus on clinical evaluation, development of green extraction methods, exploration of macro- and microalgae metabolites, and design of novel vasorelaxant derivatives while ensuring sustainable marine resource use.
  • Published in:Marine Drugs,
  • Study Type:Review, Special Issue Editorial,
  • Source: PMID: 41440896, DOI: 10.3390/md23120462
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