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Skin Improvement with Antioxidant Effect of Yuja (Citrus junos) Peel Fractions: Wrinkles, Moisturizing, and Whitening

Summary

Yuja, a citrus fruit traditionally used in Asian medicine, shows promising benefits for skin health. This study found that extracts from Yuja peels can help reduce wrinkles, improve skin moisture, and lighten dark spots by protecting skin cells from UV damage and reducing harmful free radicals. The effects work through natural mechanisms that boost collagen production and inhibit melanin overproduction, making Yuja peel fractions promising ingredients for new skincare products.

Background

Yuja (Citrus junos) has been traditionally used in China and Korea for food and medicinal purposes. UVB radiation causes cellular stress and reactive oxygen species (ROS) production, contributing to skin aging through loss of elasticity and collagen degradation. This study evaluated the antioxidant, anti-wrinkle, moisturizing, and whitening effects of Yuja-peel fractions.

Objective

To evaluate the anti-wrinkle, moisturizing, and whitening effects of Yuja-peel (YJP) fractions through molecular mechanism approaches in HaCaT, HDF, and B16F10 cells. The study aimed to measure Pro-Collagen I, hyaluronic acid content, matrix metalloproteinase expression, and melanin synthesis.

Results

YJP fractions inhibited MMP-1, -9, and -13 expression while restoring Collagen I and Pro-Collagen content in UVB-irradiated cells. YJP fractions increased hyaluronic acid, filaggrin, and serine palmitoyltransferase expression to restore skin moisturization. In B16F10 cells, YJP fractions decreased melanin content, tyrosinase activity, and melanogenic enzyme expression (MITF, TRP-1, TRP-2) induced by α-MSH.

Conclusion

Yuja-peel fractions demonstrate significant anti-wrinkle, moisturizing, and whitening effects through antioxidant mechanisms at low toxicity. These results support the development of novel skin-improving cosmetics and pharmaceuticals using YJP fractions as active ingredients. The study validates the traditional use of citron peel and expands potential applications in skincare.
  • Published in:Antioxidants (Basel),
  • Study Type:In Vitro Cell Culture Study,
  • Source: PMID: 36670913, DOI: 10.3390/antiox12010051
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