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Seven New Drimane-Type Sesquiterpenoids from Cultures of Fungus Phellinus tuberculosus

Summary

This research discovered seven new chemical compounds from a wood-rotting fungus called Phellinus tuberculosus. These findings help us better understand the chemical makeup of fungi and their potential benefits. Impacts on everyday life: • Advances our understanding of natural antioxidant sources • Contributes to the discovery of new natural compounds that could have medicinal applications • Helps understand how fungi break down wood, which is important for forest ecology • May lead to development of new natural preservatives or pharmaceutical compounds • Demonstrates the untapped potential of fungi as sources of useful chemicals

Background

Phellinus is a genus of fungi in the family Hymenochaetaceae that causes white rot. Its fruiting bodies grow on wood and are resupinate, sessile and perennial with tough, woody or cork-like brown flesh. While P. tuberculosus has shown antioxidant and radical scavenging activity, its chemical constituents had not been previously reported.

Objective

To isolate and characterize new chemical compounds from cultures of the fungus Phellinus tuberculosus.

Results

Seven new drimane-type sesquiterpennoids named phellinuins A-G (compounds 1-7) were isolated along with one known compound, 3β,11,12-trihydroxydrimene (8). The structures of the new compounds were determined through detailed spectroscopic analysis including NMR, MS, and IR data.

Conclusion

The study successfully isolated and characterized seven previously unknown drimane-type sesquiterpenoids from P. tuberculosus cultures, expanding our knowledge of the chemical constituents of this fungal species.
  • Published in:Natural Products and Bioprospecting,
  • Study Type:Chemical Analysis,
  • Source: 10.1007/s13659-014-0002-x
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