Secondary Metabolites of Isaria cicadae and Isaria tenuipes: Bioactive Compounds and Safety Concerns
- Author: mycolabadmin
- 2018-12-21
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Summary
This research examines the chemical compounds produced by two medicinal mushrooms commonly used in Asian traditional medicine and health foods. While these fungi have beneficial properties, some of their compounds can be toxic, raising important safety concerns for consumers.
Impacts on everyday life:
• Highlights the need for better safety testing of traditional medicinal mushrooms
• Suggests the importance of quality control standards for mushroom-based health products
• Helps consumers make more informed decisions about fungal supplements
• Demonstrates the dual nature of natural products as both beneficial and potentially harmful
• Emphasizes the importance of proper regulation of traditional medicine products
Background
Isaria cicadae and Isaria tenuipes are important entomopathogenic fungi used in health foods and traditional herbal medicines in East Asia. Both fungi belong to the anamorph of Cordyceps genus and are popular mushrooms that infect insects, particularly cicada nymphs, leading to their death before producing white fruit bodies used in traditional medicines.
Objective
To survey the secondary metabolites (SMs) of both fungal species to improve the safety of their fungal products, given increasing safety concerns about their consumption.
Results
For I. cicadae, key secondary metabolites include nucleosides, amino acids, beauvericins, myriocin, and oosporein. I. tenuipes produces trichothecene derivatives, isariotins, cyclopenta benzopyrans and polyketides. Several compounds from both species showed toxicity, including beauvericins, myriocin, oosporein and many trichothecene derivatives. The toxicity and side effects of fungal products may be related to these secondary metabolites.
Conclusion
To ensure product safety, residue standards for secondary metabolites need to be established and methods for their detection must be developed. Additionally, biological identification of fungal strains and standardized quality control measures are necessary. The review provides new insights into the secondary metabolites of these medical and edible fungi while highlighting important safety considerations.
- Published in:RSC Advances,
- Study Type:Review,
- Source: 10.1039/c8ra09039d