Review of Pharmacological Effects of Antrodia Camphorata and its Bioactive Compounds
- Author: mycolabadmin
- 2011-01-03
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Summary
Antrodia camphorata is a rare medicinal mushroom found only in Taiwan that shows remarkable potential for treating various diseases. This comprehensive review reveals its powerful therapeutic properties, particularly in fighting cancer and boosting immune function. The mushroom contains numerous beneficial compounds that work together to provide health benefits.
Impacts on everyday life:
• Could provide new treatment options for various types of cancer
• May help protect liver health and function
• Shows potential as a natural anti-inflammatory supplement
• Could boost immune system function naturally
• May serve as a source of powerful antioxidants for general health maintenance
Background
Antrodia camphorata is a unique mushroom of Taiwan that has been traditionally used as medicine for protecting diverse health conditions. It is a fungal parasite found in the inner cavity of the endemic species Cinnamomum kanehirae (Bull camphor tree). Historically used by Taiwanese aborigines as a traditional prescription for discomforts caused by alcohol drinking or exhaustion, it is believed to preserve human vitality and promote longevity.
Objective
To review and discuss the biological activities of crude extracts and main bioactive compounds of A. camphorata, translating this Eastern medicine into Western-accepted therapy. The review aims to comprehensively analyze pharmacological effects and chemical constituents of this medicinal mushroom.
Results
Over 78 compounds were identified from A. camphorata, including terpenoids, benzenoids, lignans, benzoquinone derivatives, succinic and maleic derivatives, and polysaccharides. The extracts and compounds showed multiple biological activities including anti-cancer, anti-inflammatory, immunomodulatory, hepatoprotective, anti-oxidant, anti-HBV, and neuroprotective effects. Triterpenoids with ketonic functional groups showed particularly potent cytotoxic activity against various cancer cell lines.
Conclusion
A. camphorata can be considered an efficient alternative phytotherapeutic agent or synergizer in treating cancer and immune-related diseases. While extensive preclinical evidence exists for its therapeutic potential, clinical trials in humans are limited. Mass production issues may hamper development of medicines from A. camphorata. Further clinical studies are needed to confirm traditional uses through rational phytotherapy.
- Published in:Evidence-based Complementary and Alternative Medicine,
- Study Type:Review,
- Source: 10.1093/ecam/nep108