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Research on the Action and Mechanism of Pharmacological Components of Omphalia lapidescens

Summary

Omphalia lapidescens, a medicinal fungus used in traditional Chinese medicine, contains multiple bioactive compounds with promising health benefits. These compounds can fight parasitic infections, inhibit cancer cell growth, reduce inflammation, and provide antioxidant protection. While clinical use shows benefits especially for gastric cancer when combined with chemotherapy, more research is needed to understand how these compounds work and to improve cultivation and production methods.

Background

Omphalia lapidescens is a medicinal fungus used in traditional Chinese medicine for antiparasitic and digestive properties. Active ingredients including proteins, polysaccharides, and sterols have demonstrated antiparasitic, anti-inflammatory, and antitumor effects. While cytotoxicity and anticancer studies exist, investigation of natural metabolites remains limited.

Objective

This review aims to comprehensively analyze research progress on pharmacological components of Omphalia lapidescens. The focus is on classifying metabolites and elucidating their mechanisms of action to provide reference for further in-depth study and explore potential medical value.

Results

The review identifies major active components including proteases, lectins, polysaccharides (S-4001, S-4002, OL-1, OL-2, OL-3), triterpenes (eburicoic acid, ganoderic compounds), and ergosterols with diverse biological activities. These components exhibit antiparasitic, antitumor, anti-inflammatory, and antioxidant properties through multiple mechanisms including JAK-STAT pathway inhibition and caspase-3 activation.

Conclusion

O. lapidescens shows significant therapeutic potential with low toxicity and favorable safety profile. Further research into genomic data, amino acid sequencing, substrate specificity, and cultivation optimization is needed to advance commercialization and clinical applications in cancer treatment and parasitic disease management.
  • Published in:International Journal of Molecular Sciences,
  • Study Type:Review,
  • Source: PMID: 39456798, DOI: 10.3390/ijms252011016
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