Recombination Suppression and Evolutionary Strata Around Mating-Type Loci in Fungi: Documenting Patterns and Understanding Evolutionary and Mechanistic Causes

Summary

This research examines how fungi control and maintain their mating systems through changes in their DNA organization. The study reveals that fungi have evolved sophisticated mechanisms to prevent genetic mixing in certain chromosomal regions, particularly around genes that determine mating compatibility. This helps maintain distinct mating types and ensures successful reproduction. Impacts on everyday life: – Improved understanding of fungal reproduction could help control harmful fungal diseases in crops and humans – Better knowledge of genetic evolution helps us understand how species adapt and survive – Insights into mating systems could aid in breeding beneficial fungi for agriculture and medicine – Understanding fungal genetics contributes to biotechnology applications like enzyme production – This research provides models for studying similar processes in other organisms, including humans

Background

Genomic regions determining sexual compatibility often display recombination suppression, as occurs in sex chromosomes, plant self-incompatibility loci and fungal mating-type loci. Regions lacking recombination can extend beyond the genes determining sexes or mating types, by several successive steps of recombination suppression. The suppression of recombination at mating-type loci in fungi has long been recognized and maintains the multiallelic combinations required for correct compatibility determination.

Objective

To review the evidence for recombination suppression around mating-type loci in fungi, sometimes encompassing vast regions of the mating-type chromosomes. To discuss testable hypotheses for the ultimate (evolutionary) and proximate (mechanistic) causes for such expansions of recombination suppression.

Results

The review found extensive evidence for recombination suppression extending beyond mating-type determining genes in fungi, occurring through multiple independent events across different fungal lineages. Several mechanisms were identified including deleterious allele sheltering, neutral rearrangements fixed by drift, and transposable element accumulation with associated epigenetic modifications. The suppression can span large chromosomal regions and occurs even in species without sexual antagonism.

Conclusion

Recent progress in sequencing technologies has revealed increasing cases of recombination suppression around fungal mating-type genes, though their evolutionary and proximate causes remain understudied. Fungi represent excellent models to test general hypotheses about recombination suppression causes due to their small genomes, decoupling of mating types from gamete size differences, and experimental tractability. Further research is needed to assess pattern generality and understand the evolutionary genomics of reproductive compatibility across organisms.
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