Pulmonary Schizophyllum Commune Infection Developing Mucoid Impaction of the Bronchi
- Author: mycolabadmin
- 2007-09-01
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Summary
This case study describes a rare fungal infection of the lungs caused by Schizophyllum commune, a fungus commonly found on dead wood. The infection caused thick mucus plugs to form in the patient’s airways, which were successfully treated with antifungal medication. This research is significant because it highlights an emerging pathogen that doctors should consider when diagnosing respiratory conditions.
Impacts on everyday life:
• Raises awareness about environmental fungi that can cause respiratory infections
• Demonstrates the importance of proper identification of fungal infections for effective treatment
• Shows that antifungal medications can be effective for certain types of airway blockages
• Highlights the need to consider fungal causes in persistent respiratory symptoms
• Emphasizes the importance of long-term follow-up in fungal respiratory conditions
Background
Mucoid impaction of the bronchi (MIB) is an uncommon condition characterized by dilatation and filling of bronchi with thick mucoid material. It typically occurs as a hypersensitivity response in bronchial asthma or allergic bronchopulmonary mycosis (ABPM). Schizophyllum commune is a basidiomycetes fungus found throughout Japan on dead wood and fallen trees that has recently been identified as a causative agent of MIB and ABPM.
Objective
To report and analyze a case of mucoid impaction of the bronchi caused by Schizophyllum commune infection that improved with itraconazole treatment.
Results
Bronchoscopy revealed thick white mucous plugs in both B3 bronchi that could not be removed mechanically. Cultures yielded Schizophyllum commune, confirmed through specialized mating tests. After 3 months of itraconazole treatment, symptoms improved and bronchoscopy showed disappearance of mucous plugs. No recurrence was observed during 7 years of follow-up.
Conclusion
While Aspergillus fumigatus is the most common cause of allergic bronchopulmonary mycosis, Schizophyllum commune should be considered in cases of mucoid impaction of bronchi where Aspergillus is not detected. Antifungal treatment with itraconazole may be effective in treating MIB caused by S. commune infection.
- Published in:Yale Journal of Biology and Medicine,
- Study Type:Case Study,
- Source: PMID: 18299722