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Psilocybin: Systematic review of its use in the treatment of depression

Summary

Researchers reviewed scientific studies on psilocybin, a psychedelic compound found in certain mushrooms, as a treatment for depression. The studies showed that psilocybin significantly reduced depressive symptoms faster than standard treatments, with minimal side effects. This suggests psilocybin could be a promising new option for people with depression who haven’t benefited from traditional medications.

Background

Psilocybin is a psychedelic compound that has demonstrated potential in treating depression, particularly in cases resistant to conventional treatments. This systematic review examines the current scientific evidence regarding its therapeutic applications.

Objective

To evaluate the therapeutic effects of psilocybin for the treatment of depressive disorder through a comprehensive systematic review of current scientific literature published between 2019-2024.

Results

Included studies demonstrated significant improvements in depressive symptoms with psilocybin compared to standard treatments. Results showed rapid and sustained symptom reduction with few adverse effects reported.

Conclusion

Psilocybin appears to be an effective and safe alternative for treating depression, offering symptomatic relief with fewer treatment sessions and a favorable safety profile. Further research is needed to fully understand its therapeutic potential and underlying mechanisms.
  • Published in:European Psychiatry,
  • Study Type:Systematic Review,
  • Source: 10.1192/j.eurpsy.2025.926
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