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Psilocybin Does Not Induce Conditioned Place Preference, But Modifies Behavioral Patterns in Sprague-Dawley Rats

Summary

Researchers tested whether psilocybin, a compound found in magic mushrooms, could be addictive by examining reward-seeking behavior in rats. The study found that psilocybin did not create rewarding effects that would typically lead to addiction, and only temporarily changed specific behaviors like head-twitching and grooming while the drug was active. These findings suggest that psilocybin has a low addiction potential and may be safe for therapeutic use in treating mental health conditions.

Background

Recent years have seen renewed scientific interest in psychedelics, including psilocybin, for their potential in treating neuropsychiatric disorders. However, the reward-related properties and behavioral impacts of a high dose of psilocybin remain insufficiently explored.

Objective

To assess the potential rewarding properties of a high dose of psilocybin (10 mg/kg i.p.) in the conditioned place preference (CPP) paradigm and analyze its effects on rat behavior.

Results

RM two-way ANOVA showed no significant difference in time spent in psilocybin-paired compartment compared to vehicle. Psilocybin administration led to modifications in behavioral profile with increased head-twitching, dog-shaking, and defecation, but decreased grooming, body licking, and rearing. No behavioral differences were found 48 hours after the last injection.

Conclusion

Psilocybin is not linked to rewarding properties in the CPP paradigm, supporting its safety profile and therapeutic potential. Psychedelics act primarily through serotonergic mechanisms which may mitigate drug craving and reduce dopamine-related reinforcing effects. No long-term behavioral changes or physical dependence were observed.
  • Published in:International Journal of Neuropsychopharmacology,
  • Study Type:Experimental Animal Study,
  • Source: 10.1093/ijnp/pyaf052.229
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