Prospective Study on Microbiological Profile of Fungal Isolates and its Antibiogram in a Tertiary care hospital in South India
- Author: mycolabadmin
- 1/29/2025
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Summary
Researchers studied fungal infections in a hospital in South India over one year, examining 62 fungal isolates. They found that Candida auris, a dangerous fungal species, was the most common and had developed resistance to many antifungal drugs. A newer class of antifungal drugs called echinocandins worked best against these infections, highlighting the importance of quick identification of fungal species for proper treatment.
Background
Fungal infections are increasingly recognized as significant causes of morbidity and mortality, particularly in immunocompromised individuals. There is limited data on the microbiological profile and antimicrobial resistance patterns of fungal isolates in South India. This prospective study aims to characterize fungal isolates and determine their antibiograms in a tertiary care hospital.
Objective
To characterize fungal isolates and determine their antibiograms in a tertiary care hospital in South India, providing crucial insights for clinical management and infection control strategies.
Results
A total of 62 fungal isolates were isolated with average patient age of 49 years, higher prevalence in males (n=42). Azoles, Polyenes and Echinocandins were susceptible in 57%, 76% and 80% of cases respectively. Candida auris was the most common isolate, developing complete resistance to azoles and partial resistance to polyenes, while echinocandins showed reliable efficacy.
Conclusion
Candida auris was the most resistant species identified, with echinocandins being the most reliable antifungal drug choice compared to azoles and polyenes. The study highlights the need for rapid diagnostic procedures to enable timely identification and rational antifungal therapy.
- Published in:Open Forum Infectious Diseases,
- Study Type:Prospective Observational Study,
- Source: 10.1093/ofid/ofae631.2302, PMC11779103