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Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

Summary

Researchers studied yeast infections in urine from hospitalized patients using advanced molecular testing. They found that while Candida albicans was most common, other yeast species were becoming more resistant to antifungal medications. The study used a 21-tube PCR test to identify different yeast species and tested which medications worked best against them. Results showed that newer yeast species were much more likely to resist commonly used antifungal drugs like fluconazole.

Background

Candiduria, a urinary tract infection caused by Candida species, is among the most prevalent invasive fungal infections. While Candida albicans remains the most frequently isolated species, non-albicans Candida (NAC) species are increasingly prevalent with rising antifungal resistance rates.

Objective

To assess the prevalence and antifungal susceptibility patterns of Candida isolates from patients diagnosed with candiduria using a 21-plex PCR assay and determine species-specific resistance patterns.

Results

Candida albicans was the predominant species (70%), followed by C. tropicalis (11%), C. glabrata (9%), and C. parapsilosis (5%). Fluconazole resistance was 2.86% in C. albicans but 29.41% in NAC species. NAC species showed significantly higher resistance to antifungal agents compared to C. albicans.

Conclusion

Candida albicans remains the predominant etiological agent of candiduria; however, NAC species exhibit higher resistance rates to fluconazole and other antifungals. The 21-plex PCR system successfully identified candiduria agents, supporting the need for accurate species identification and antifungal susceptibility testing in clinical management.
  • Published in:Current Medical Mycology,
  • Study Type:Cross-sectional observational study,
  • Source: PMID: 41122123
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