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Polyphenolic Hispolon Derived from Medicinal Mushrooms of the Inonotus and Phellinus Genera Promotes Wound Healing in Hyperglycemia-Induced Impairments

Summary

Researchers tested a natural compound called hispolon, extracted from medicinal mushrooms, to see if it could help heal wounds in diabetic patients. Using both laboratory cells and diabetic rats, they found that hispolon successfully reduced cell damage caused by high blood sugar, improved wound closure, and promoted healthy tissue growth. The compound worked as well as an existing diabetic wound cream and showed no harmful side effects, suggesting it could become a new natural treatment option for diabetic wound complications.

Background

Wound healing is impaired in diabetic patients due to hyperglycemia-induced oxidative stress, leading to chronic wounds and complications such as diabetic foot ulcers. Hispolon is a polyphenolic pigment extracted from medicinal mushrooms with known antioxidant and anti-inflammatory properties. This study investigates hispolon’s potential as a therapeutic agent for diabetic wound healing.

Objective

To comprehensively evaluate the wound-healing properties of hispolon under hyperglycemic conditions using both in vitro and in vivo models. The study aims to assess hispolon’s mechanisms of action in enhancing wound healing and compare its efficacy to Fespixon® cream, an established diabetic wound treatment.

Results

Hispolon improved fibroblast viability, suppressed oxidative stress markers (ROS, lipid peroxidation, DNA damage), and enhanced migration in high-glucose conditions. In diabetic rats, 5% hispolon ointment accelerated wound contraction, reduced epithelialization time, enhanced tissue regeneration, modulated macrophage polarization, and improved wound-breaking strength comparably to Fespixon® cream.

Conclusion

Hispolon demonstrates significant potential as a therapeutic candidate for diabetic wound management by mitigating oxidative stress, enhancing tissue regeneration, and accelerating wound healing through modulation of inflammatory responses and collagen synthesis.
  • Published in:Nutrients,
  • Study Type:In Vitro and In Vivo Experimental Study,
  • Source: PMID: 39861396
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