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Pleurotus sajor-caju-Mediated Synthesis of Silver and Gold Nanoparticles Active Against Colon Cancer Cell Lines: A New Era of Herbonanoceutics

Summary

This research demonstrates a new way to create cancer-fighting nanoparticles using mushroom extract. Scientists developed silver and gold nanoparticles using extracts from the oyster mushroom Pleurotus sajor-caju, which showed promising results against colon cancer cells. The approach combines traditional herbal medicine with modern nanotechnology. Impacts on everyday life: • Offers a potential new treatment option for colon cancer patients • Demonstrates how natural ingredients can be combined with advanced technology for better medical treatments • Shows promise for developing safer cancer treatments with fewer side effects • Provides a sustainable and environmentally friendly way to produce medical nanoparticles • Could lead to more affordable cancer treatments using natural resources

Background

Herbal medicines are widely used worldwide due to fewer side effects and ability to treat root causes of diseases. While nanotechnology shows promise for cancer treatment, it faces challenges in clinical settings. Active phyto ingredients need scientific approaches and mechanisms to distribute components at target sites for better therapeutic results.

Objective

To develop and compare silver and gold nanoparticles synthesized using Pleurotus sajor-caju mushroom extract through a novel microwave-assisted green synthesis method, and evaluate their anticancer effects against colon cancer cells. The study aimed to demonstrate a new ‘herbonanoceutics’ approach combining benefits of herbal active ingredients with nanosystems.

Results

Both Ag and Au nanoparticles showed face-centered cubic structures and were nanocrystalline in nature, with sizes of 15-20 nm for Ag NPs and 16-18 nm for Au NPs. The nanoparticles demonstrated cytotoxic effects against HCT-116 colon cancer cells with IC50 values of 50 μg/mL for Ag NPs and 80 μg/mL for Au NPs. Silver nanoparticles showed higher cytotoxicity and ROS generation compared to gold nanoparticles and mushroom extract alone.

Conclusion

The novel synthesis method successfully created uniform silver and gold nanoparticles with active phyto ingredients capped on their surface. Silver nanoparticles demonstrated superior anticancer activity against colon cancer cells compared to gold nanoparticles and mushroom extract alone. This herbonanoceutics approach combines benefits of herbal active ingredients with nanosystems, showing promise for enhanced cancer therapeutics.
  • Published in:Molecules,
  • Study Type:Laboratory Research,
  • Source: 10.3390/molecules25133091
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