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Phytochemical Composition and Wound Healing Properties of Echinacea angustifolia DC. Root Hydroalcoholic Extract

Summary

Echinacea angustifolia, a traditional medicinal plant, was studied for its wound-healing abilities using laboratory tests. Scientists found that the plant extract contains powerful antioxidant compounds, particularly one called echinacoside, and can help skin cells move and multiply to close wounds faster. The extract also reduces inflammation and protects cells from damage, supporting its long-standing traditional use for treating wounds and burns.

Background

Echinacea angustifolia has been traditionally used for wound healing and burns. Natural products are increasingly being explored for treating skin conditions and wounds due to their therapeutic potential.

Objective

To evaluate the phytochemical composition, antioxidant, anti-inflammatory, and wound-healing properties of Echinacea angustifolia root hydroalcoholic extract using in vitro models and analyze its efficacy compared to known wound-healing compounds.

Results

HPLC analysis identified six polyphenols with echinacoside as the predominant compound (63181.24 mg/kg). The extract showed strong antioxidant properties, demonstrated no cytotoxicity, and significantly increased 3T3-L1 cell migration in wound healing assays. Treatment reduced proinflammatory cytokines (TNF-α, IL-1β, IL-6) and increased TGF-β1 expression, promoting wound closure.

Conclusion

E. angustifolia root hydroalcoholic extract demonstrates significant wound healing potential through antioxidant and anti-inflammatory mechanisms. The synergistic action of multiple compounds, particularly echinacoside, supports its traditional use for wound healing, providing scientific rationale for its therapeutic applications.
  • Published in:International Journal of Molecular Sciences,
  • Study Type:In vitro Experimental Study,
  • Source: PMID: 40141204, DOI: 10.3390/ijms26062562
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