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Phytochemical Analysis and Anti-Ulcer Potential of Phenolic Compounds of Inonotus nidus-pici Pilát

Summary

Researchers studied a wood mushroom called Inonotus nidus-pici to understand its healing potential. They found it contains beneficial compounds like quercetin and rosmarinic acid that act as antioxidants. When tested on rats with chemically-induced stomach ulcers, the mushroom extract provided protection similar to common ulcer medications, suggesting it could help prevent stomach damage from pain relievers.

Background

Fungotherapy represents an important therapeutic approach in traditional medicine. Inonotus nidus-pici Pilát is a wood-destroying mushroom related to Chaga (Inonotus obliquus) but with limited scientific research on its phytochemical composition and biological properties.

Objective

To analyze the phytochemical composition of phenolic compounds in Inonotus nidus-pici and evaluate its antioxidant activity and gastroprotective effects against indomethacin-induced gastric ulcers in experimental rat models.

Results

The enriched phenolic extract contained tannins (1.67%), phenolic acids (1.50%), and flavonoids (1.24%). Quercetin (15.95 mg/g DWE) was the most abundant flavonoid, followed by catechin (9.86 mg/g DWE). Rosmarinic acid was the predominant phenolic acid (6.41 mg/g DWE). The extract demonstrated strong antioxidant capacity and dose-dependent gastroprotective effects comparable to famotidine at 25 mg/kg dose.

Conclusion

Inonotus nidus-pici is a promising source of bioactive phenolic compounds with antioxidant and gastroprotective properties. The phenolic fraction shows potential for preventing gastric ulcers when used concomitantly with NSAIDs, supporting further chemical and pharmacological research.
  • Published in:Pharmaceuticals (Basel),
  • Study Type:Experimental Study,
  • Source: 10.3390/ph18091265, PMID: 41011136
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