Phenolic Rich Fractions from Mycelium and Fruiting Body of Ganoderma lucidum Inhibit Bacterial Pathogens Mediated by Generation of Reactive Oxygen Species and Protein Leakage and Modulate Hypoxic Stress in HEK 293 Cell Line

This research examined how compounds extracted from the medicinal mushroom Ganoderma lucidum can fight bacteria and protect cells from low-oxygen stress. The scientists found that certain extracts from both the mushroom’s fruiting body and root-like structure had strong antioxidant properties and could kill harmful bacteria by disrupting their cells. The extracts also helped protect kidney cells from damage caused by low oxygen conditions. Impacts on everyday life: – Could lead to new natural antibiotics to fight bacterial infections – May help develop treatments for conditions involving low oxygen in tissues – Demonstrates the potential health benefits of medicinal mushrooms in supplements – Provides scientific support for traditional uses of Ganoderma in Asian medicine – Shows promise for developing natural preservatives and antioxidants