MYCOLab Ai Logo - gold and army green

Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India

Summary

This study describes five cases of a serious fungal infection called mucormycosis that started in the mouth following dental procedures like tooth extraction. All patients had uncontrolled diabetes, which made them vulnerable to this infection. The infection was treated with antifungal medications and surgery, with good recovery. The findings highlight how important it is for dentists to follow strict hygiene practices and for diabetic patients to keep their blood sugar controlled before dental work.

Background

Mucormycosis is an angio-invasive opportunistic fungal infection affecting immunocompromised individuals, particularly those with uncontrolled diabetes. While rhino-orbital-cerebral mucormycosis (ROCM) is well-described, odontogenic-onset mucormycosis (OOM) is an emerging clinical entity characterized by a unique port of entry through dental procedures with distinct clinical features.

Objective

To report a series of five cases of odontogenic-onset mucormycosis managed at a tertiary care center in North India, highlighting the clinical, radiological, and histopathological features of this distinct form of mucormycosis and emphasizing the need for heightened awareness among dental practitioners.

Results

Five cases of OOM were identified, developing 2-6 weeks following dental procedures (tooth extraction or root canal therapy). All patients had uncontrolled or poorly controlled diabetes. Radiological features showed osteolytic lesions in the alveolar-basal region. All cases were treated with surgical debridement and liposomal amphotericin B followed by oral posaconazole, with significant clinical improvement and favorable outcomes.

Conclusion

This case series underscores OOM as a distinct clinical entity with better prognosis than ROCM. Heightened awareness and strict aseptic precautions during dental procedures are critical for dental practitioners. Early diagnosis and prompt intervention combining antifungal therapy and surgical management are essential for favorable outcomes.
  • Published in:Medical Mycology Case Reports,
  • Study Type:Case Series,
  • Source: PMID: 41017794, DOI: 10.1016/j.mmcr.2025.100730
Scroll to Top