Occurrence of Pathogenic and Allergenic Molds in the Outdoor and Indoor Environment of a Major Hospital and Molecular Epidemiology of Aspergillus fumigatus in Kuwait
- Author: mycolabadmin
- 1/21/2025
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Summary
Researchers in Kuwait found many types of mold in and around a hospital, with some being resistant to common antifungal medications. They discovered that the same mold species were found both outdoors and in the hospital environment, suggesting patients could catch infections from the surrounding air. The study identified molds that could cause serious infections in vulnerable patients and found that about 10% of environmental samples contained drug-resistant strains that were also found in sick patients.
Background
Aspergilli and other molds are prevalent in the environment and cause opportunistic infections and seasonal allergies in susceptible patients. Kuwait’s arid climate and extensive plantation drives have led to higher spore counts of common molds including drug-resistant strains in outdoor and indoor air.
Objective
This study determined species distribution of various molds in outdoor and indoor air of a major hospital and performed antifungal susceptibility testing and molecular fingerprinting of environmental and clinical Aspergillus fumigatus isolates in Kuwait.
Results
A total of 6179 isolates were obtained with Cladosporium (37%), Aspergillus (22%), and Penicillium (21%) being most common. Itraconazole-resistant A. fumigatus with TR34/L98H mutations were recovered from outdoor air, hospital environment, and clinical samples. Fingerprinting showed shared genotypes among outdoor air and hospital environmental isolates.
Conclusion
The presence of shared genotypes among outdoor air and hospital environment including triazole-resistant A. fumigatus suggests an environmental reservoir for invasive infections. Regular resistance surveillance programs are recommended for immunocompromised hospitalized patients.
- Published in:Journal of Fungi (Basel),
- Study Type:Environmental surveillance study,
- Source: PMID: 39997377, DOI: 10.3390/jof11020083