MYCOLab Ai Logo - gold and army green

Nutraceutical supplement slim reshaped colon histomorphology and reduces Mucispirillum schaedleri in obese mice

Summary

Researchers tested a supplement called Slim containing natural compounds like berberine, coenzyme Q10, and beet pulp on obese mice. After 4 weeks, the supplement improved cholesterol and triglyceride levels, increased beneficial gut bacteria, and strengthened the intestinal barrier. The results suggest this combination of natural ingredients works together synergistically to improve gut health and metabolic function in obesity.

Background

Obesity is linked to gut microbiota dysbiosis and metabolic syndrome. Bioactive compounds and whole foods have emerged as promising interventions to address these conditions. The gut microbiota plays a crucial role in regulating immune system and energy metabolism in obese individuals.

Objective

This study evaluated the effects of a nutraceutical supplement called Slim on the modulation of gut microbiota, lipid metabolism, and colon histomorphology in obese mice induced by a high-fat diet. The supplement contains berberine, coenzyme Q10, beet pulp, prebiotics, minerals, and yeast β-glucans.

Results

Slim supplementation significantly reduced VLDL cholesterol and triglycerides, increased goblet cells and Lieberkühn crypts in the colon, and expanded Peyer’s patches and Auerbach plexus. The supplement decreased Mucispirillum schaedleri abundance and reduced phyla Cyanobacteria and Deferribacteres while increasing Proteobacteria.

Conclusion

The Slim nutraceutical supplement demonstrated a duplibiotic effect through synergistic action of its bioactive compounds, improving lipid metabolism and reshaping colon histomorphology in obese mice. These effects were correlated with reduced levels of pathogenic bacteria and improved gut microbiota composition, suggesting potential therapeutic benefits for obesity-related metabolic dysbiosis.
  • Published in:Frontiers in Microbiology,
  • Study Type:Preclinical Animal Study,
  • Source: 40236479
Scroll to Top