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Neurite Outgrowth Stimulatory Effects of Myco Synthesized AuNPs from Hericium erinaceus on Pheochromocytoma (PC-12) Cells

Summary

This research demonstrates how gold nanoparticles made using lion’s mane mushroom (Hericium erinaceus) extract can promote nerve cell growth. The study shows a natural, environmentally-friendly way to produce nanoparticles that could potentially help treat nerve-related conditions. Impacts on everyday life: – Provides a potential natural treatment option for neurological conditions – Demonstrates an eco-friendly way to produce medical nanoparticles – Shows new medicinal applications for edible mushrooms – Could lead to better treatments for nerve damage and regeneration – Offers hope for neurodegenerative disease treatments

Background

Hericium erinaceus has demonstrated various medicinal properties including stimulation of neurite outgrowth, promotion of nerve injury recovery, and antioxidant effects. Green synthesis of gold nanoparticles (AuNPs) has gained interest for biomedical applications. The study investigated whether AuNPs synthesized from H. erinaceus aqueous extract could stimulate neurite outgrowth in rat pheochromocytoma (PC-12) cells.

Objective

To investigate the effects of gold nanoparticles (AuNPs) synthesized from aqueous extract of Hericium erinaceus on neurite outgrowth of rat pheochromocytoma (PC-12) cells.

Results

The synthesized AuNPs showed maximum absorbance between 510-600 nm, with spherical shapes and sizes of 20-40 nm. FTIR confirmed the presence of proteins and polysaccharides as capping agents. The AuNPs demonstrated significant neurite extension effects on PC-12 cells, with maximum neurite outgrowth of 13% observed at 600 ng/mL concentration. The neurite stimulation was dose-dependent and comparable to nerve growth factor (NGF) positive control.

Conclusion

This study successfully demonstrated a simple, low-cost and rapid bioreduction approach for AuNPs synthesis. The synthesized AuNPs showed potential for neuronal differentiation and stimulated neurite outgrowth, likely due to water-soluble bioconstituents. This represents the first report of AuNPs biosynthesis using hot aqueous extract of H. erinaceus and their neurotrophic effects.
  • Published in:International Journal of Nanomedicine,
  • Study Type:In Vitro Study,
  • Source: 10.2147/IJN.S88371
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