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Naphthrene Compounds from Mycelial Fermentation Products of Marasmius berteroi

Summary

This research discovered new chemical compounds from a tropical mushroom species that could potentially be useful in developing treatments for diseases. The compounds showed promising activity in inhibiting an enzyme linked to neurological conditions and in fighting cancer cells. Impacts on everyday life: – Provides new leads for developing anti-cancer medications – Contributes to potential treatments for neurological disorders – Demonstrates the value of studying mushrooms for medical purposes – Highlights the importance of preserving biodiversity for drug discovery – Shows how traditional medicine sources can lead to modern therapeutic agents

Background

The genus Marasmius is a common basidiomycete found in tropical and subtropical areas that produces diverse metabolites with potential bioactive properties. Previous studies have identified various compounds like terpenoids, steroids, cyclic peptides, isocoumarins and piperidones from Marasmius species, showing antibacterial, cytotoxic and antihypertensive activities. Marasmius berteroi is a small orange mushroom widely distributed in southeast China, but its chemical constituents have been little researched.

Objective

To explore and identify novel bioactive metabolites from the fungus Marasmius berteroi through deep chemical investigation of its mycelial fermentation products.

Results

Three new naphthalene compounds (dipolynaphthalenes A-B and naphthone C) and twelve known compounds were isolated and characterized. Compounds 2-4 and 7 showed acetylcholinesterase inhibitory activity with inhibition ratios of 42.74%, 44.63%, 39.50% and 51.49% respectively at 50 μg/mL. Compounds 5, 7, and 8 exhibited cytotoxic activity against K562 and SGC-7901 tumor cell lines.

Conclusion

The study successfully identified novel naphthalene compounds from M. berteroi with promising acetylcholinesterase inhibitory and cytotoxic activities. The findings demonstrate the potential of this fungal species as a source of bioactive natural products and contribute to our understanding of Marasmius secondary metabolites.
  • Published in:Molecules,
  • Study Type:Laboratory Research,
  • Source: 10.3390/molecules25173898
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