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Modulation of Abortiporus biennis Response to Oxidative Stress by Light as a New Eco-Friendly Approach with a Biotechnological Perspective

Summary

Researchers studied how a type of fungus called Abortiporus biennis responds to stress created by a chemical compound (menadione) and different colors of light. They found that combining white light with menadione dramatically increased the production of laccase, an important enzyme used in industrial applications. This discovery offers an inexpensive, non-toxic way to boost enzyme production without using expensive chemical additives, potentially improving medical and industrial uses of this fungus.

Background

White rot fungi like Abortiporus biennis possess sophisticated mechanisms for responding to oxidative stress and have significant biotechnological potential for producing bioactive compounds. Light and chemical stressors can modulate fungal metabolism and enzyme production through complex signaling pathways.

Objective

This study aimed to comprehensively explore the impact of menadione-induced oxidative stress combined with light at various wavelengths on the metabolism and biochemical markers of the white rot fungus Abortiporus biennis using phenotypic analysis and biochemical assessment.

Results

Menadione and green/red light significantly affected metabolic activity and metabolic efficiency. The fungus showed highest superoxide anion radical levels in darkness and red light conditions. Menadione substantially stimulated laccase activity, particularly under white light conditions (5.6-6.8 fold increase by day 10), while inhibiting catalase and superoxide dismutase activities. The most substantial antioxidative effect was observed on day 5 in green light conditions.

Conclusion

The biochemical response of A. biennis to light- and menadione-induced oxidative stress is complex and multidirectional, with synergistic effects between the two stressors. The combination of eco-friendly, non-toxic menadione and white light shows promise for enhancing industrial laccase production without relying on costly chemical inducers, providing a basis for improving biotechnological and medicinal applications of this fungus.
  • Published in:International Journal of Molecular Sciences,
  • Study Type:Experimental Study,
  • Source: PMID: 40564949, DOI: 10.3390/ijms26125482
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