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Microminutinin, a Fused Bis-Furan Coumarin from Murraya euchrestifolia, Exhibits Strong Broad-Spectrum Antifungal Activity by Disrupting Cell Membranes and Walls

Summary

Researchers discovered a natural compound called microminutinin from a plant used in traditional medicine. This compound shows strong ability to kill various fungal pathogens that damage crops, particularly tea plants. The compound works by breaking down the protective structures of fungal cells, making it a promising candidate for developing safer, plant-based fungicides for agriculture.

Background

Plant fungal diseases threaten crop production and safety. Natural products are important sources for developing new green fungicides. Previous studies showed Murraya euchrestifolia has antibacterial activity, but its antifungal properties and active compounds were unknown.

Objective

To isolate and identify antifungal compounds from Murraya euchrestifolia extract and evaluate their broad-spectrum antifungal activity and mechanism of action against plant pathogenic fungi.

Results

Microminutinin, a fused bis-furan coumarin, was isolated for the first time from Murraya genus. It exhibited strong broad-spectrum antifungal activity with EC50 of 11.33 μg/mL against Pestalotiopsis theae, comparable to carbendazim. Microscopy revealed mycelial morphological damage, and biochemical assays demonstrated disruption of cell membrane integrity and cell wall structure.

Conclusion

Microminutinin has potential to be developed into a new botanical fungicide or lead compound. The compound disrupts fungal cell membranes and walls, making it a promising candidate for field application in controlling plant fungal diseases.
  • Published in:Plants (Basel),
  • Study Type:Experimental Research,
  • Source: 10.3390/plants14213392, PMID: 41225942
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