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Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder

Summary

Scientists discovered a beneficial bacteria called Enterococcus faecalis HY0110 from bluefin tuna that could help protect gut health and fight harmful pathogens better than current probiotics. This marine bacteria produces important compounds like acetic acid that kill disease-causing bacteria, reduce inflammation in inflammatory bowel disease, and even slows cancer cell growth. When fermented with cockroach powder, it creates powerful health-boosting compounds that could make functional foods more effective for managing digestive diseases and supporting overall wellness.

Background

Inflammatory bowel disease, antimicrobial resistance, and colorectal cancer represent escalating global health burdens. Marine-derived probiotics offer potential therapeutic alternatives leveraging unique selective pressures from extreme environments. Enterococcus faecalis isolated from marine fish presents opportunities for developing next-generation functional foods with enhanced bioactivity.

Objective

To comprehensively evaluate the multifunctional properties of marine-derived Enterococcus faecalis HY0110 through in vitro and in vivo assessments including antibacterial activity, antioxidant capacity, anti-tumor effects, and its synergistic fermentation with Periplaneta americana extract to enhance nutritional and bioactive profiles.

Results

HY0110 demonstrated superior gastrointestinal tolerance, antibacterial efficacy, and antioxidant capacity compared to Lactobacillus rhamnosus GG, with acetic acid strongly correlating with antimicrobial activity. In the colitis model, HY0110 restored pro-inflammatory cytokines to control levels and shifted microbial community assembly toward deterministic processes. Fermentation of P. americana powder with HY0110 generated 668.73-fold increase in astragaloside A alongside increases in bioactive amino acids and peptides.

Conclusion

HY0110 represents a promising marine-derived probiotic for functional food applications with demonstrated multifaceted benefits including antimicrobial activity, immune modulation, gut microbiota restoration, and anti-tumor potential. The synergistic fermentation with insect-derived substrates offers innovative approaches to precision nutrition and inflammatory disease management while advancing sustainable functional food development.
  • Published in:Foods,
  • Study Type:In Vitro and In Vivo Study,
  • Source: 10.3390/foods14071181, PMC11988638, 40238337
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