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Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model

Summary

This study examined whether consuming large amounts of Chaga mushroom can damage the kidneys in rats. The researchers found that high-dose Chaga consumption led to kidney injury through accumulation of oxalate (a naturally occurring compound in the mushroom), causing oxidative damage and cell death in kidney tissue. The findings suggest that while Chaga mushroom is promoted as a health supplement, excessive long-term consumption may harm kidney function, particularly in susceptible individuals.

Background

Chaga mushroom is widely consumed as a medicinal supplement with purported antioxidant and anti-inflammatory properties. However, Chaga contains high levels of oxalate, which can accumulate in kidneys and cause renal injury. Recent clinical cases have reported chronic kidney disease development following prolonged Chaga mushroom consumption.

Objective

To investigate whether chronic dietary intake of Chaga mushroom induces renal injury by examining effects on renal function, histopathological changes, oxidative stress, inflammation, and apoptosis in a rat model.

Results

High-dose Chaga consumption resulted in lower final body weight, significantly elevated urinary protein excretion, and calcium oxalate crystal deposition in kidney tubules. Oxidative stress markers, inflammatory cells, and apoptotic markers were significantly increased in the high-dose group compared to controls.

Conclusion

Prolonged and excessive Chaga mushroom consumption induces kidney injury through oxalate accumulation, oxidative stress, inflammation, and apoptosis. These findings suggest the need for safe consumption guidelines and careful monitoring of kidney function in regular Chaga mushroom consumers.
  • Published in:Journal of Korean Medical Science,
  • Study Type:Experimental Animal Study,
  • Source: PMID: 41555803
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