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Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities

Summary

Researchers extracted and identified six chemical compounds from A. blazei mushrooms and tested their ability to fight fungal infections. The compounds showed promising activity against common fungal pathogens that cause infections in humans. This research suggests that A. blazei could be developed into natural antifungal treatments. The findings add to growing evidence that medicinal mushrooms contain valuable bioactive compounds with therapeutic potential.

Background

Agaricus blazei Murrill is a valuable medicinal and edible fungus native to Brazil and various regions of Asia. While extensively studied for anti-tumor and immune-regulating effects, its antifungal properties and non-polysaccharide chemical compounds remain largely unexplored.

Objective

This study aimed to isolate and identify chemical compounds from A. blazei using spectroscopic methods and evaluate their in vitro antifungal activities against pathogenic fungi.

Results

Six compounds were identified: linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24S)-ergosta-7-en-3-ol, and dibutyl phthalate. Compounds showed varying antifungal sensitivities, with compound 2 showing significant inhibition against T. mentagrophytes, compound 3 against T. rubrum, and compound 6 against C. albicans.

Conclusion

This study demonstrates the antifungal potential of A. blazei compounds and provides the first evidence of these specific compounds in the fungus. Future research should explore synergistic effects and in vivo validation to develop novel antifungal therapeutic agents.
  • Published in:Molecules,
  • Study Type:Experimental Research,
  • Source: PMID: 37959740, DOI: 10.3390/molecules28217321
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