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Investigation of the In Vitro Antioxidant, Anticholinesterase, Antiurease, Antityrosinase, and Cytotoxic Properties of a Novel Compound: 4-Methoxy-2-(4-Methoxyphenyl)Benzo[d][1,3,2]Dioxaborole

Summary

Scientists created a new chemical compound containing boron that showed promise as a potential medicine. The compound was effective at neutralizing harmful molecules in cells and inhibiting enzymes related to Alzheimer’s disease. Importantly, it did not damage healthy cells or kill cancer cells, suggesting it could be safe for future medical applications in treating various diseases.

Background

Boron compounds have been used in healthcare for their positive effects on cancer treatment, cardiovascular health, bone health, wound healing, and immune function. Boronic acids are known for their low inherent toxicity and antimicrobial properties. This study synthesized a novel 3-methoxy catechol boron derivative marking its first appearance in scientific literature.

Objective

To synthesize and characterize a novel boron compound (4-Methoxy-2-(4-Methoxyphenyl)Benzo[d][1,3,2]Dioxaborole) using 3-methoxy catechol and 4-methoxy phenyl boronic acid, and to evaluate its antioxidant, anticholinesterase, antiurease, antityrosinase, and cytotoxic properties.

Results

The compound demonstrated high antioxidant activity with IC50 values superior to reference standards α-TOC and BHT at 10 μg/mL concentration. Acetylcholinesterase inhibition was significantly higher than galantamine, though butyrylcholinesterase showed no significant difference. Urease and tyrosinase inhibition activities were lower than standards. The compound showed no toxic effects on healthy cells and no cytotoxic effects on MCF-7 breast cancer or HT-29 colon cancer cell lines.

Conclusion

The synthesized 3-methoxy catechol boron derivative demonstrates significant therapeutic potential with strong antioxidant and acetylcholinesterase inhibitory properties. The compound’s selective lack of cytotoxicity against healthy cells while maintaining anticancer potential suggests promise for future medicinal and industrial applications. Further development is warranted for cancer treatment research and pharmaceutical ingredient development.
  • Published in:Pharmacology Research & Perspectives,
  • Study Type:In Vitro Experimental Study,
  • Source: PMID: 39786313, DOI: 10.1002/prp2.70044
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