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Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism

Summary

Researchers studied chaga mushroom (Inonotus obliquus) and found it helps muscles grow stronger and regenerate better. When mice were given chaga extract, their muscles became larger and stronger after injury, particularly through increased energy production in muscle cells. The mushroom works by activating specific proteins that promote muscle growth and boost the mitochondria (the energy factories) in muscle cells, suggesting it could help prevent age-related muscle weakness.

Background

Skeletal muscle wasting related to aging and pathological conditions is associated with increased incidence of secondary diseases including cardiovascular disease and metabolic syndromes. Inonotus obliquus (chaga mushroom) has been used in traditional medicine for inflammation, cardiovascular disease, and diabetes, but its effects on muscle health have not been explored.

Objective

To investigate the beneficial effects of Inonotus obliquus extract on muscle regeneration, metabolism, and function using in vitro and in vivo models.

Results

IO treatment increased myogenic differentiation and alleviated dexamethasone-induced myotube atrophy through AKT activation and suppression of ubiquitin E3 ligases. In mice, IO improved muscle regeneration, elevated mitochondrial content, and increased oxidative metabolism accompanied by PGC-1α induction. IO-treated muscles displayed enhanced proliferation of muscle stem cells and improved oxidative capacity.

Conclusion

Inonotus obliquus is a promising natural agent that enhances muscle regenerative capacity and oxidative metabolism through AKT and PGC-1α activation, thereby preventing muscle wasting related to aging and pathological conditions.
  • Published in:International Journal of Biological Sciences,
  • Study Type:Experimental Study,
  • Source: 10.7150/ijbs.84970; PMID: 37781506
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