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Inonotus obliquus – From Folk Medicine to Clinical Use

Summary

This research examines the medicinal mushroom Inonotus obliquus (chaga) and its potential health benefits. The study shows that this traditional medicinal mushroom contains powerful compounds that can fight cancer cells, reduce inflammation, boost immunity, and help manage diabetes. Here’s how this research impacts everyday life: • Could provide a natural supplement option for supporting immune system health • May offer an additional treatment option for managing diabetes and blood sugar levels • Shows potential as a natural antioxidant supplement to protect cells from damage • Could help develop new cancer treatments or supportive therapies • Validates traditional medicine practices and identifies natural compounds for modern medical use

Background

Inonotus obliquus (chaga mushroom) has been traditionally used to treat various gastrointestinal diseases. It has a long history of use in folk medicine dating back to Hippocrates, who used infusions externally to wash wounds. In Eastern Europe, it has been used since the 12th century for various medicinal purposes including antiparasitic, anti-tuberculosis, anti-inflammatory and gastrointestinal properties.

Objective

This review aims to summarize the therapeutic potential of I. obliquus extracts in counteracting the progression of cancers and diabetes mellitus as well as their antiviral and antiparasitic activities and antioxidant role. The study evaluates current scientific findings on the biological properties of I. obliquus and explores potential medical applications.

Results

Research shows I. obliquus exhibits multiple beneficial properties including antioxidant, anti-inflammatory, immunomodulatory, antiviral, antiparasitic, anti-cancer and antidiabetic effects. Two main mechanisms of action were identified: 1) Impact on antioxidant enzymes and reactive oxygen species (ROS) levels, and 2) Effects related to peroxisome proliferator-activated receptor gamma (PPARγ). The mushroom contains bioactive compounds including polysaccharides, triterpenoids, polyphenols and melanin that contribute to its therapeutic properties.

Conclusion

I. obliquus fits the definition of functional food and demonstrates potentially positive effects on health beyond basic nutrition. While showing promise in various therapeutic applications, particularly for cancer and diabetes, more clinical studies meeting evidence-based medicine criteria are needed to fully validate its medical use.
  • Published in:Journal of Traditional and Complementary Medicine,
  • Study Type:Review,
  • Source: 10.1016/j.jtcme.2020.08.003
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