Inhibition of IgE-Dependent Mouse Triphasic Cutaneous Reaction by a Boiling Water Fraction Separated from Mycelium of Phellinus Linteus
- Author: mycolabadmin
- 2005-09-01
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Summary
This research investigated how different extracts from the medicinal mushroom Phellinus linteus affect allergic skin reactions in mice. The study found that compounds extracted using boiling water were most effective at reducing allergic reactions while also boosting immune system function. This discovery is significant for developing natural treatments for allergies.
Impacts on everyday life:
• Could lead to new natural antihistamine medications with fewer side effects
• Offers potential new treatments for allergic skin conditions
• Demonstrates how traditional medicinal mushrooms can be used in modern medicine
• Shows promise for developing dual-action treatments that both fight allergies and boost immunity
• Provides scientific support for using natural mushroom extracts in health supplements
Background
Phellinus linteus is a mushroom known to exhibit potent antitumor activity through activating immune cells. While its immunopotentiating properties are well documented, its anti-inflammatory and anti-allergic properties have been less studied. Recent research has suggested P. linteus may possess anti-allergic and anti-inflammatory properties alongside its immunomodulating effects.
Objective
To investigate the anti-allergic properties of different fractions isolated from P. linteus mycelium using an IgE-dependent mouse triphasic cutaneous reaction model. The study aimed to identify which fraction exhibits the strongest anti-allergic effects.
Results
The BW fraction showed the most potent inhibition of all three phases of the cutaneous reaction at doses of 30-300 mg/kg. BW inhibited vascular permeability increase caused by passive cutaneous anaphylaxis and histamine, as well as ear swelling caused by TNF-α. Interestingly, BW potentiated the production of both IL-4 and IFN-γ from anti-CD3-stimulated mouse splenocytes.
Conclusion
The boiling water-soluble fraction (BW) derived from P. linteus mycelium contains constituents with both anti-allergic and immunopotentiating properties. The active compounds, likely polysaccharides, demonstrate potential as therapeutic agents for allergic conditions while maintaining immune-enhancing effects.
- Published in:Evidence-based Complementary and Alternative Medicine,
- Study Type:Laboratory Research,
- Source: 10.1093/ecam/neh105