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In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents

Summary

This research examined how Lion’s Mane mushroom extracts made with different liquids can fight infections and oxidative damage. The water-based extract was best at preventing viruses and free radical damage, while the ethyl acetate extract worked best against bacteria and fungi. The study identified 16 beneficial compounds in the mushroom and suggests it could be used as a daily supplement to protect against infections and oxidative stress.

Background

Infectious diseases are a major global health threat and antibiotic resistance is increasing. Edible mushrooms possess various medicinal properties and bioactive compounds that may provide antimicrobial, antiviral, and antioxidant benefits with fewer side effects than synthetic compounds.

Objective

This study investigated whether solvent polarity affects the extraction quality and biological activities of Hericium erinaceus fruiting bodies, assessing antimicrobial, antiviral, antioxidant, and anti-inflammatory properties against various pathogens and identifying chemical constituents.

Results

Aquatic extract showed superior antioxidant (IC50=53.7 µg/mL) and antiviral (IC50=24.97 µg/mL) activities, while ethyl acetate extract demonstrated the best antimicrobial activity. All extracts exhibited low anti-inflammatory action. GC-MS identified 16 compounds including quercetin and Lucenin-2 with various biological activities.

Conclusion

H. erinaceus mushroom extracts exhibit promising antimicrobial, antiviral, and antioxidant activities, though anti-inflammatory activity was limited. The mushroom represents a potential source for natural therapeutic bioactive compounds, and further isolation and characterization of active compounds is warranted.
  • Published in:Bioresources and Bioprocessing,
  • Study Type:In vitro experimental study,
  • Source: PMID: 38647811, DOI: 10.1186/s40643-022-00592-6
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