MYCOLab Ai Logo - gold and army green

In Vitro Assessment of Multipotential Therapeutic Importance of Hericium erinaceus Mushroom Extracts Using Different Solvents

Summary

This research examined the medicinal properties of Lion’s Mane mushroom (Hericium erinaceus) extracts and their potential health benefits. The study found that different extracts of the mushroom showed promising abilities to fight harmful microorganisms, protect against viruses, and act as antioxidants. This has important implications for everyday life: • The mushroom could be used as a natural supplement to boost immune system function • It may help protect against bacterial infections that are resistant to conventional antibiotics • The antioxidant properties could help prevent cellular damage and aging • It could be developed into natural preservatives for food products • The findings support including this mushroom as part of a healthy diet for its protective benefits

Background

Infectious diseases are a major threat to human health and the second leading cause of death worldwide. Many deaths occur due to lack of access to antimicrobial compounds. Edible mushrooms have nutritional and medicinal properties that can help combat microbial resistance with fewer side effects compared to synthetic antimicrobials.

Objective

To evaluate the therapeutic potential of Hericium erinaceus mushroom extracts using different solvents for antimicrobial, antiviral, antioxidant and anti-inflammatory activities. The study aimed to determine how solvent polarity affects extraction quality and subsequent biological activities.

Results

The aqueous extract showed significant antioxidant (IC50= 53.7 µg/mL) and antiviral (IC50= 24.97 µg/mL) activities. Ethyl acetate extract demonstrated the strongest antimicrobial activity against tested microorganisms. All extracts showed low anti-inflammatory action. GC-MS analysis revealed 16 different compounds, with 13 in ethyl acetate extract and 6 in aqueous extract. Key compounds included quercetin derivatives and Lucenin-2 with known biological activities.

Conclusion

H. erinaceus extracts demonstrated promising antimicrobial, antiviral, and antioxidant activities while showing low anti-inflammatory effects. The aqueous extract was particularly effective for antioxidant and antiviral applications, while ethyl acetate extract showed superior antimicrobial activity. The mushroom contains various bioactive compounds that could be valuable for therapeutic applications.
  • Published in:Bioresources and Bioprocessing,
  • Study Type:In Vitro Study,
  • Source: 10.1186/s40643-022-00592-6
Scroll to Top