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Immunomodulatory Effects of a Mycelium Extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): A Randomized and Double-Blind Clinical Trial

Summary

This research examined how a mushroom extract from Cordyceps fungus affects human immune system function. The study found that taking Cordyceps extract supplements for 8 weeks helped boost important immune cells called natural killer (NK) cells, which help fight infections and cancer. The supplement was safe with no significant side effects. Impacts on everyday life: • Provides a natural way to strengthen immune system function • Offers a safe supplement option for maintaining health • Makes beneficial compounds from rare Himalayan Cordyceps more widely available • Demonstrates scientific support for traditional medicine practices • Could help protect against infections and support overall wellness

Background

Cordyceps is a traditional Chinese herb known for various biopharmaceutical effects including immune enhancement. Natural Cordyceps sinensis (CS) is difficult to mass gather as it grows only at high altitudes around the Himalaya Mountains. Recent developments in artificial cultivation have enabled mass production of CS mycelium through Paecilomyces hepiali, containing bioactive substances like nucleosides and polysaccharides similar to natural CS.

Objective

To confirm the immunoregulatory efficacy and safety of CBG-CS-2 (a mycelium extract from Paecilomyces hepiali isolated from Cordyceps sinensis) in healthy Korean adults.

Results

The CBG-CS-2 group showed a significant 38.8 ± 17.6% enhancement from baseline in NK cell cytotoxic activity compared to the placebo group after 8 weeks of supplementation (P < 0.019). No significant changes were observed in serum cytokine levels between groups.

Conclusion

CBG-CS-2 supplementation effectively enhanced cell-mediated immunity in healthy adults by increasing NK cell activity without causing inflammation. The extract was found to be both safe and effective for immune system enhancement.
  • Published in:BMC Complementary and Alternative Medicine,
  • Study Type:Clinical Trial,
  • Source: 10.1186/s12906-019-2483-y
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