Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

This research examines how immune cells (macrophages) respond differently to active versus dormant forms of a dangerous fungus called Cryptococcus neoformans. The dormant form causes the immune cells to accumulate fatty acids differently than the active fungus, which may help the fungus establish long-term infections. Understanding these differences could lead to better treatments for cryptococcal infections, which are particularly dangerous for immunocompromised individuals.