Hybrid nanoencapsulation systems: integrating natural polymers with synthetic nanomaterials for enhanced delivery of bioactive compounds in functional foods

Author: mycolabadmin
12/2/2025
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Summary

Hybrid nanoencapsulation systems combine natural polymers with synthetic nanomaterials to better protect and deliver beneficial compounds in functional foods. These systems improve the stability and absorption of nutrients like vitamins, antioxidants, and probiotics that would otherwise break down during processing or digestion. Various manufacturing methods such as electrospinning and self-assembly enable precise control of particle size and release, making functional foods more effective for health benefits.

Background

Bioactive compounds such as polyphenols, vitamins, and antioxidants are incorporated into functional foods to support health benefits, but their application is limited by low water solubility, instability during processing, and rapid degradation. Traditional encapsulation systems fall short in achieving optimal protection and targeted delivery. Hybrid nanoencapsulation systems combining natural polymers with synthetic nanomaterials offer a promising solution to overcome individual material limitations.

Objective

This review comprehensively examines hybrid nanoencapsulation systems that integrate biocompatible natural polymers (chitosan, alginate, starch) with synthetic nanomaterials (PLGA, PEG, mesoporous silica) for functional food applications. The review aims to synthesize recent developments in material selection, chemical and enzymatic modifications, nano-fabrication techniques, and smart stimuli-responsive systems for precision nutrient delivery.

Results

Hybrid systems demonstrate enhanced encapsulation efficiency, improved physicochemical stability, and controlled release of bioactives. Examples include chitosan-coated PLGA nanoparticles, amphiphilic chitosan-curcumin nanomicelles, electrospun pullulan-citrus pectin fibers for astaxanthin encapsulation, and pH-responsive curcumin-Fe3O4/chitosan/agarose composites. Modified biopolymers and stimuli-responsive polymers enable site-specific, on-demand release.

Conclusion

Hybrid nanoencapsulation systems represent a promising approach for optimizing bioactive delivery in functional foods by synergistically combining natural polymer biocompatibility with synthetic polymer precision. While significant advances have been made in material development and fabrication techniques, challenges remain in scalable manufacturing, safety validation, regulatory compliance, and consumer acceptance. Future research should prioritize green synthesis methods, food-grade material innovation, and comprehensive risk assessment.

Published in:Nanoscale Advances,
Study Type:Review,
Source: 41220488