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High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms

Summary

This study examines bamboo mushroom extracts for their ability to promote skin wound healing. Researchers tested three different parts of immature bamboo mushrooms and found that the core extract was particularly effective at reducing inflammation and preventing excessive collagen breakdown, which helps wounds heal properly without excessive scarring. The extract performed as well as or better than standard pharmaceutical agents, suggesting it could be a promising natural ingredient for wound healing products.

Background

Dictyophora indusiata (bamboo mushroom) is used in traditional medicine and functional foods with reported biological activities. While mature fruiting bodies have been extensively studied, research on immature bamboo mushroom extracts and their wound healing applications is limited.

Objective

To investigate bioactive compound contents and wound healing effects of aqueous extracts from three parts of immature D. indusiata mushrooms (peel-green mixture, core, and whole mushroom), evaluating anti-inflammatory activity and collagen stimulation through MMP-2 inhibition.

Results

All D. indusiata extracts demonstrated antioxidant potential and significant anti-inflammatory activity. The core extract (CW) containing high catechin content (68.761 mg/g) suppressed NO secretion (0.06 µmol/L) better than diclofenac standard, with MMP-2 inhibition (41.33%) comparable to L-ascorbic acid (50.65%).

Conclusion

The core extract of immature D. indusiata showed promising wound healing properties through anti-inflammatory and collagen-stimulating mechanisms, supporting its potential as a natural active ingredient for pharmaceutical and cosmeceutical wound healing products.
  • Published in:Journal of Fungi,
  • Study Type:In Vitro Experimental Study,
  • Source: PMC8708927, PMID: 34947082, DOI: 10.3390/jof7121100
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