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Health-Promoting Properties of Polysaccharides Extracted from Ganoderma lucidum

Summary

This research examines the health benefits of compounds called polysaccharides found in the medicinal mushroom Ganoderma lucidum. These natural compounds show promise in supporting health through multiple mechanisms, including boosting antioxidant defenses, modulating immune function, protecting brain cells, and helping regulate blood sugar levels. Impacts on everyday life: • Could provide a natural supplement option for supporting immune system health • May help protect against age-related cognitive decline and neurodegenerative conditions • Shows potential as a complementary approach for managing blood sugar levels and diabetes • Offers a natural antioxidant source to help combat cellular damage and aging • Represents a bridge between traditional medicine and modern scientific validation of natural remedies

Background

Ganoderma lucidum is a medicinal mushroom that has been used for centuries in traditional Chinese medicine. It is rich in bioactive compounds, particularly polysaccharides, which have demonstrated various pharmacological effects. The polysaccharides from G. lucidum show antioxidant, immunomodulatory, antineurodegenerative and antidiabetic properties.

Objective

This review aims to summarize and analyze the various biological activities and mechanisms of action of polysaccharides extracted from Ganoderma lucidum, with a focus on their health-promoting properties and potential therapeutic applications.

Results

The review found that GLP demonstrates significant antioxidant properties by inducing antioxidant enzymes and reducing oxidative stress markers. It shows immunomodulatory effects through activation of immune cells and regulation of cytokine production. GLP exhibits neuroprotective properties by reducing inflammation and amyloid toxicity. It also demonstrates antidiabetic effects by improving insulin sensitivity and reducing blood glucose levels.

Conclusion

Polysaccharides from Ganoderma lucidum show promising potential as natural therapeutic agents due to their diverse pharmacological properties. While current research demonstrates significant health benefits, further clinical trials are needed to fully understand their therapeutic potential and safety profile for medical applications.
  • Published in:Nutrients,
  • Study Type:Review,
  • Source: 10.3390/nu13082725
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