Green Myco-Synthesis of Zinc Oxide Nanoparticles Using Cortinarius sp.: Hepatoprotective, Antimicrobial, and Antioxidant Potential for Biomedical Applications

Author: mycolabadmin
4/22/2025
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Summary

Researchers used mushroom extracts to create tiny zinc oxide particles in an environmentally friendly way. These nanoparticles were tested in mice with liver damage and showed significant protective effects. The particles also demonstrated strong abilities to fight bacteria and fungal infections while acting as powerful antioxidants, suggesting potential use in future medical treatments.

Background

Nanotechnology is revolutionizing medicine by introducing new therapeutic approaches. This study explores the eco-friendly synthesis of zinc oxide nanoparticles using mushroom extract as a reducing agent, addressing the need for environmentally sustainable alternatives to chemical synthesis methods.

Objective

This study aimed to synthesize zinc oxide myco-nanoparticles (ZnO-MNPs) using Cortinarius sp. extract and evaluate their hepatoprotective, antimicrobial, and antioxidant potential for biomedical applications.

Results

XRD analysis confirmed hexagonal wurtzite structure with absorption peak at 378 nm. ZnO-MNPs significantly reduced hepatotoxicity markers (ALT, ASAT, ALP, LDH, MDA) and restored antioxidant parameters (GSH, catalase). Antimicrobial testing showed potent activity against Bacillus subtilis (29.05 ± 0.76 mm), Bacillus meurellus (27.05 ± 0.5 mm), and other pathogens, with DPPH assay confirming strong antioxidant properties.

Conclusion

ZnO-MNPs synthesized from Cortinarius sp. demonstrate significant hepatoprotective, antimicrobial, and antioxidant potential. These findings highlight the effectiveness of myco-synthesized ZnO-NPs as promising candidates for combating pathogenic diseases, supporting cancer therapy development, and serving as biomaterial options for future therapeutic applications.

Published in:Microorganisms,
Study Type:Experimental Study,
Source: PMID: 40431129