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Green Myco-Synthesis of Zinc Oxide Nanoparticles Using Cortinarius sp.: Hepatoprotective, Antimicrobial, and Antioxidant Potential for Biomedical Applications

Summary

Scientists created tiny particles called zinc oxide nanoparticles using mushroom extract in an environmentally friendly way. These particles were tested and found to protect the liver from damage, kill harmful bacteria and fungi, and act as powerful antioxidants. This research suggests these mushroom-derived nanoparticles could become useful medicines for treating infections and cancer in the future.

Background

Nanotechnology is revolutionizing medicine with new therapeutic approaches. Chemical synthesis of nanoparticles is environmentally harmful, prompting the need for eco-friendly green synthesis methods. Mushrooms are effective biological agents for synthesizing nanoparticles due to their natural secretion of enzymes, proteins, and other bioactive molecules.

Objective

To explore the green myco-synthesis of zinc oxide nanoparticles (ZnO-MNPs) using Cortinarius sp. mushroom extract as a reducing agent. To evaluate the hepatoprotective, antimicrobial, and antioxidant potential of these biosynthesized ZnO-MNPs for biomedical applications.

Results

ZnO-MNPs showed a hexagonal wurtzite structure with absorption peak at 378 nm. Treatment with ZnO-MNPs significantly reduced hepatotoxic effects of CCl4, lowering elevated liver enzymes (ALT, ASAT, ALP, LDH) and bilirubin levels while restoring antioxidant markers (GSH, catalase). ZnO-MNPs demonstrated strong antibacterial activity against Bacillus subtilis, Bacillus meurellus, Acetobacter rhizospherensis, and Escherichia coli, with antifungal activity against Aspergillus flavus and Mucor mucedo, and showed 40.1% DPPH radical scavenging antioxidant activity.

Conclusion

Cortinarius sp.-derived ZnO-MNPs were successfully synthesized using eco-friendly green myco-synthesis. The ZnO-MNPs demonstrated significant hepatoprotective, antimicrobial, and antioxidant properties, highlighting their potential as promising candidates for antipathogenic drug development and therapeutic applications in combating pathogenic diseases and cancer therapy.
  • Published in:Microorganisms,
  • Study Type:In vivo experimental study,
  • Source: PMID: 40431129, DOI: 10.3390/microorganisms13050956
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