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Global status and trends of invasive pulmonary aspergillosis: A bibliometric study

Summary

This study analyzes 24 years of research on invasive pulmonary aspergillosis, a serious fungal infection in immunocompromised patients. Using bibliometric tools, researchers mapped out how the field has evolved, identifying leading countries (USA, Germany, China), key experts like David Denning and Thomas Walsh, and shifting research focus from transplant-related infections to COVID-19-associated cases. The analysis shows the field is rapidly growing with increasing emphasis on rapid diagnostic methods and antifungal therapies.

Background

Invasive pulmonary aspergillosis (IPA) is a severe opportunistic infection affecting immunocompromised patients with high mortality rates. Recent evidence suggests IPA can also occur in non-immunocompromised hosts, particularly in critically ill ICU patients. Previous studies have explored pathophysiology and epidemiology, but comprehensive research trends and hotspots remain largely unexplored.

Objective

To develop a visual knowledge map using bibliometric analysis to identify research hotspots, key contributors, and predict future trends in IPA research. The study aims to assess contributions by countries, institutions, journals, and authors while identifying seminal references and emerging research themes.

Results

Analysis of 4058 articles from 3409 institutions across 749 journals and 214 countries/regions. The United States led in publications (1312) and citations (81,386). Four major research themes identified: diagnostics, clinical management, at-risk populations, and COVID-19-associated IPA. Three distinct research phases identified with shifting focus from bone marrow transplantation to COVID-19-associated IPA.

Conclusion

Bibliometric analysis identified key authors, institutions, and journals driving IPA research. The field shows three distinct phases of evolution with recent emphasis on COVID-19-associated IPA. David W. Denning and Thomas J. Walsh are leading authorities. Findings provide insights for future collaborations and research directions in IPA investigation.
  • Published in:Medicine (Baltimore),
  • Study Type:Bibliometric Analysis,
  • Source: PMID: 40441187, DOI: 10.1097/MD.0000000000042603
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