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Ganoderma lucidum inspired silver nanoparticles and its biomedical applications with special reference to drug resistant Escherichia coli isolates from CAUTI

Summary

Researchers created tiny silver particles using a medicinal mushroom called Ganoderma lucidum to fight dangerous bacteria that resist antibiotics and are associated with urinary catheter infections. These nanoparticles were found to effectively kill drug-resistant bacteria, work as antioxidants better than a common antioxidant standard, and showed promise in killing breast cancer cells. This eco-friendly approach offers a natural alternative to conventional antibiotics for treating serious antibiotic-resistant infections.

Background

Catheter-associated urinary tract infections (CAUTI) are a significant healthcare burden caused by drug-resistant bacteria forming biofilms. Silver nanoparticles synthesized through bioengineered sources represent an alternative therapeutic approach. Ganoderma lucidum, a medicinal mushroom with rich bioactive compounds, has been explored for its antimicrobial and therapeutic potential.

Objective

To synthesize silver nanoparticles using Ganoderma lucidum extracts and evaluate their antimicrobial activity against drug-resistant Escherichia coli isolates from catheter-associated urinary tract infections, as well as assess their antioxidant and anticancer potential.

Results

GC-MS identified 27 bioactive compounds with ethyl acetoacetate ethylene acetal as the major component (72.2%). Silver nanoparticles ranged from 23-58 nm with spherical morphology. GL-AgNPs showed effective inhibition of drug-resistant E. coli with inhibition zones of 13.6-16.8 mm at 75 µL concentration. Antioxidant activity exceeded quercetin standard, and IC50 for MDA-MB-231 breast cancer cells was 9.2 µg/mL.

Conclusion

Ganoderma lucidum-derived silver nanoparticles exhibit multifocal biomedical potential with significant antimicrobial, antioxidant, and anticancer activities. The synthesized GL-AgNPs represent an eco-friendly and cost-effective alternative therapeutic approach for combating drug-resistant bacterial infections and cancer. The bioactive compounds in G. lucidum enhance the nanoparticles’ therapeutic efficacy through protein capping mechanisms.
  • Published in:Saudi Journal of Biological Sciences,
  • Study Type:Experimental/Laboratory Study,
  • Source: PMID: 33100858, DOI: 10.1016/j.sjbs.2020.09.008
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