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Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress

Summary

Researchers studied a natural supplement made from reishi mushroom and black locust flower to treat kidney disease. In laboratory and animal tests, this supplement reduced kidney damage by lowering harmful molecules called free radicals and controlling inflammation. The supplement worked by blocking specific pathways that cause kidney inflammation and scarring, suggesting it could be a helpful natural treatment for people with chronic kidney disease.

Background

Chronic kidney disease is characterized by functional and structural abnormalities strongly influenced by oxidative stress and inflammatory responses, ultimately leading to renal fibrosis. Ganoderma lucidum and Robinia pseudoacacia are medicinal plants with known antioxidant and anti-inflammatory properties, though their role in kidney disease remains largely unexplored.

Objective

This study aimed to investigate the effects of a Ganoderma lucidum and Robinia pseudoacacia flower extract complex (NEPROBIN) on kidney inflammation and fibrosis through in vitro and in vivo experiments.

Results

NEPROBIN significantly alleviated H2O2-induced oxidative stress, suppressed MAPK and NF-κB signaling pathways, and reduced inflammatory cytokine expression in renal cells. In mice, NEPROBIN treatment reduced kidney damage markers, decreased oxidative stress, mitigated inflammatory responses, and significantly reduced tubulointerstitial fibrosis.

Conclusion

NEPROBIN effectively alleviated renal damage and fibrosis by directly targeting oxidative stress and inflammation, highlighting its potential as a therapeutic agent for chronic kidney disease through suppression of MAPK and NF-κB pathways.
  • Published in:Antioxidants (Basel),
  • Study Type:In Vitro and In Vivo Experimental Study,
  • Source: 40298637
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