Fungal and Microalgal Chitin: Structural Differences, Functional Properties, and Biomedical Applications
- Author: mycolabadmin
- 10/10/2025
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Summary
Chitin is a natural fiber found in mushroom cell walls and algae that can be extracted and used for medical applications like wound healing and drug delivery. Traditional chitin from shellfish shells contains heavy metals and requires harsh chemicals to extract, but chitin from mushrooms and algae is cleaner, more sustainable, and can be grown year-round. Scientists have developed environmentally friendly extraction methods using special solvents and enzymes that preserve the chitin’s useful properties. This makes fungal and algal chitin promising alternatives for creating biomedical materials and packaging.
Background
Chitin is the second most abundant biopolymer in nature after cellulose. Traditional commercial chitin extraction from crustacean shells faces limitations including seasonal availability, allergenic protein contamination, heavy metal residues, and environmentally harmful demineralization processes requiring 30-60% mineral removal.
Objective
This review synthesizes current advances in fungal and microalgal chitin research to establish them as sustainable alternatives to crustacean-derived chitin. The review addresses sources, preparation methods, bioactive properties, molecular mechanisms, and biomedical applications within the framework of the sustainable bioeconomy.
Results
Fungal chitin predominantly exhibits α-polymorph with high crystallinity and mechanical stability, embedded in chitin-glucan-protein matrices suitable for biomedical applications. Microalgal β-chitin from diatoms exists as high-aspect-ratio microrods and nanofibrils with parallel chain packing, providing enhanced reactivity. Green extraction technologies enable recovery with reduced environmental burden while preserving native morphology.
Conclusion
Fungal and microalgal chitin sources offer unique structural polymorphs and tunable properties as sustainable alternatives to crustacean chitin. Integration of renewable sources with environmentally friendly processing methods positions these materials as promising for biomedicine, agriculture, food packaging, and advanced materials applications.
- Published in:Polymers (Basel),
- Study Type:Review,
- Source: 10.3390/polym17202722, PMID: 41150263