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First Chemical Investigation of Korean Wild Mushroom, Amanita hemibapha subsp. javanica and the Identification of Anti-Helicobacter pylori Compounds

Summary

Researchers studied a Korean edible mushroom called Amanita hemibapha subsp. javanica and found it contains compounds that can kill the bacteria Helicobacter pylori, which causes stomach ulcers and gastric cancer. One compound in particular showed strong antibacterial activity, performing even better than some known antibiotics. These findings suggest this mushroom could be a natural source for developing new medicines to treat H. pylori infections and fight antibiotic-resistant strains.

Background

Amanita hemibapha subsp. javanica is an edible Korean wild mushroom often confused with the toxic A. subjunquillea (East Asian death cap). While previous studies showed this mushroom has antioxidant and immunomodulatory properties, its chemical constituents have never been systematically investigated.

Objective

To conduct the first comprehensive chemical investigation of A. hemibapha subsp. javanica fruiting bodies and identify bioactive compounds, particularly those with anti-Helicobacter pylori activity.

Results

Seven fatty acid derivatives and three steroids were isolated and identified. Compound 4 showed the most potent anti-H. pylori activity with 80.5% inhibition and MIC50 value of 72 μM, superior to quercetin control. Compound 3 exhibited comparable activity to quercetin with 38.0% inhibition. The presence of α,β-unsaturated carbonyl moieties appeared important for antibacterial activity.

Conclusion

A. hemibapha subsp. javanica represents a promising natural source for bioactive compounds. Compound 4 demonstrates significant potential for development as a novel antibiotic against H. pylori, offering an alternative to address rising antibiotic resistance.
  • Published in:Pharmaceuticals (Basel),
  • Study Type:Experimental Research,
  • Source: PMID: 35215265, DOI: 10.3390/ph15020152
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